The significance of sCD40L and ICAM-1 in serum and placenta of women spontaneous abortion infected by Toxoplasmosis

اهمية sCD40L و ICAM-1في مصل ومجانس المشائم للنساء ذوات الاجهاض التلقائي المصابات بداء المقوسات

Abstract

A total of 50 aborted women (spontaneous abortion) were included in this study and classified into two groups (25 for each other) infected and non-infected with toxoplasmosis, other group was from healthy women ( 25 ) . The diagnosis of infection was by direct agglutination (Latex) and Enzyme Linked Immunosorbent assay (ELISA) to detection Toxoplasma gondii specific antibodies IgG and IgM. The level both of sCD40L and ICAM-1 in pg/ml was determined in study groups serum as well as homogenate of placenta for aborted women. The findings demonstrated no significant differences in level of sCD40L in both of serum and homogenate among toxoplasmosis – induced abortion women with accidental abortion women. While levels of ICAM-1 were significant increase (P≤0.05) in both of serum and homogenate of toxoplasmosis-induced abortion women(89.88±3.10 & 96.72±2.16 pg/ml , respectively) , while serum and homogenate was recorded in accidental abortion women lower concentration ( 66.96±1.77 & 76.34±6.91 pg/ml , respectively . These results suggest that systemic production of ICAM-1 plays a significant role in induction of abortion in toxoplasmosis patients.