Effect of chemical contaminants in local bottled drinking water on Blood glucose of male and female albino mice

Abstract

Eight local commercial bottled water brands (T1, T2, T3, T4, T5, T6, T7, and T8) were subjected to an investigation regarding chemical contamination. The investigation involved at sunlight, shad, refrigerator temperature 4°C, freezing -18°C, room temperature, at different time intervals (days). Samples to various storage conditions which were; direct sun light at (45–47°C), shade, room temperatures, cold storage (4°C), freezing (at 0°C and -18°C) all for different periods. The investigated chemical contaminants were acetaldehyde, formaldehyde, ethylene glycol, diethyl hexyl phthalate, dimethyl phthalate, diethyl phthalate, butyl benzyl phthalate, dibutyl phthalate, bisphenol A, and antimony. The maximum concentration for each chemical was measured amounting to 1275.50, 256.09, 6599.09, 82.61, 4.75, 172.69, 99.00, 458.83, 104.95, 1704.3 ppb, respectively. A combination of chemical contaminants was employed to investigate their impact on the blood sugar levels of lab mice in addition to 2 other concentrations (less and greater). Significantly different blood glucose levels (of male and female mice) were determined at (P≤0.01 and P≤0.05), respectively. An increase in both male and female mice blood sugar levels was noted correlated with the increase in contaminants concentrations. These levels were greater in male mice than female mice in comparison to the control group, which amounted to (230.00 - 150.33 mg/dL and 171.49 - 149.49 mg/dL), respectively.